THC-O may be the strongest THC alternative on the market. Here’s everything you need to know about THC-O-Acetate, including serving size information and possible side effects. 

What is THC-O-Acetate? 

THC-O-Acetate, AKA THC-O, is one of the newer THC alternatives on our radar. Similar to delta-8 THC, it’s synthesized from CBD or THC. However, it isn’t found naturally in hemp, meaning t’s a fully synthetic cannabinoid. 

THC-O is similar in structure to delta-8 and delta-9 THC on a chemical level. When it’s synthesized, CBD undergoes a series of chemical reactions that replace the THC hydroxyl group with an Acetyl group. It also changes the molecule’s permeability and fat solubility, ultimately making it feel up to three times more potent than ordinary delta-9 THC. 

Because of the transformation, our bodies have a much easier time absorbing it and processing it with the endocannabinoid system. However, THC-O needs to be metabolized through the process of digestion before you can feel it. On its own, THC-O is inactive, offering no pharmacological activity. But when it’s ingested, its metabolites bind to CB1 receptors in the endocannabinoid system and cause you to feel high. Since they bind better than delta-9 molecules, they cause you to feel much higher than standard THC. 

THC-O is relatively new, so not a lot of scientific research has gone into studying its long-term effects on the body. We recommend always doing your research before exploring new THC alternatives and starting with a low dose to rule out experiencing any possible adverse effects. 

Effects and possible side effects of THC-O-acetate 

THC and THC-O acetate are very similar in structure, so they offer many of the same effects. THC may be used for stress, depression, insomnia, lack of appetite, pain, and the management of other symptoms, and THC-O isn’t much different. However, THC-O feels three times as potent as regular THC. 

While we have to rely on anecdotal evidence from people who have tested THC-O, many users agree that the most significant difference is that it feels more potent. Most people use it regularly with few side effects. Some compare it to a very high dose of edibles or more psychedelic in its physical and mental effects. That said, the high itself is different than the classic euphoria experienced with delta-9 THC. 

Further, since THC-O is absorbed more efficiently, it comes with other possible side effects. For example, the influx of a high dose of THC-O may be a source of syncope, causing your blood pressure to fall rapidly or lead to unconsciousness. Building a tolerance to THC-O and constantly taking large doses of it may also lead to Cannabinoid Hyperemesis Syndrome, which leads to long-lasting bouts of severe vomiting. Generally speaking, most people only experience the common side effects of THC, including dry eyes, cottonmouth, and the occasional too-high feeling. 

How to use THC-O 

THC-O must be ingested for it to work the most effectively. A good rule of thumb for beginners is to cut your standard THC dose into thirds. For example, if you’re used to taking 10mg of THC, start with about 3mg of THC-O to start. THC-O offers delayed effects and higher potency, so starting small and working your way up to avoid unpleasant experiences is crucial. 

With all edibles, it’s best to start with a low dose to feel out how it’ll affect you before taking more. THC-O can take up to two hours to kick in, and the effects can last up to 8 hours. Be sure to start small and gradually increase your dose until you find your desired level of relief. You should always wait at least two hours before taking another dose to prevent any uncomfortable side effects. 

Is THC-O Acetate safe? 

THC-O was discovered in the 1940s and was studied on dogs. However, little research has been conducted on humans, so the community is still unsure about its effectiveness or overall safety. Like other hemp-derived cannabinoids, there aren’t many regulations in place covering it. Unregulated products may cause health concerns and typically haven’t been tested enough to determine their proper effects. 

Synthesizing THC-O-acetate involves taking hemp-derived delta-8 THC and using chemicals to make it into THC-O. With that said, there’s a lot of potential to contaminate the final product or leave behind synthetic byproducts, unnatural isomers created by accident, or other residuals from toxic solvents, acids, or bleaching clays. 

If you’re looking to explore THC-O, be wary of a great deal and never buy from a company that doesn’t share their third-party lab results. The packaging should also proudly display ingredients and accurate milligram dosages. We’re committed to your overall wellness and safety here at The Hemptender and proudly share our lab results and ensure our products are free from impurities and other possible health concerns. 

All that said, THC-O is considered to be generally safe. Use your best judgment and consider all of the information we’ve mentioned above. If you do decide to try it, use edibles and start with a small dose to see how it’ll affect you. 

Is THC-O legal? 

Like other THC alternatives, THC-O is in a legal gray area. The Farm Bill legalized hemp-derived cannabinoids and the many different isomers of those compounds. With that said, THC-O is technically legal. However, a handful of states have banned THC-O for the similarities it shares with delta-9 THC— a Schedule I substance. Always follow state and local regulations for consuming cannabis and hemp products. 

Where to find THC-O Acetate 

If you’re looking to try THC-O for yourself, you can trust The Hemptender. We’ve been working on our own line of THC-O gummies and are proud to announce that they’ll be launching soon. In the meantime, check out all of our THC alternatives and massive array of hemp products by visiting our store or shopping online. You’ll get free shipping on orders over $75, and you can even take advantage of a 10% discount that will be automatically applied at checkout.